Melatonin is not only a chronobiotic
Speaker: Josip Čulig
Congress 2025 · 19:54 · Audio: Croatian
Lecture on melatonin, its role in sleep and circadian rhythm, and other areas of research. It also considers the limitations of evidence when interpreting research findings.
About the recording
Josip Čulig discusses melatonin from the perspective of a clinical pharmacologist considering the literature and different areas of research. He begins with sleep and circadian rhythms, then broadens the topic to research into antioxidant and anti-inflammatory mechanisms.
The lecture covers melatonin synthesis, its relationship with light and changes across the lifespan. The speaker connects biological mechanisms with the examples of laboratory and clinical research presented.
The final section includes other research areas, among them applications related to the skin. Throughout the lecture, he considers the interpretation of different types of evidence and open questions about possible uses beyond the regulation of sleep rhythms.
References and additional reading
Melatonin for prevention of erythema and oxidative stress in response to ultraviolet radiation
Scheuer C · 2017
Shown on a lecture slide
Source note: A doctoral review and related original research on melatonin and UV erythema, cited on the skin slide. Erythema outcomes do not establish prevention of skin cancer.
Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study
Scheuer C, Pommergaard HC, Rosenberg J, Gögenur I · 2016 · DOI: 10.1016/j.jdermsci.2016.08.007
Editorial additional reading
Source note: A primary trial in 23 healthy people, linked to the doctoral review cited in the lecture. It measured erythema after exposure to sunlight, rather than the incidence of skin cancer.
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